Summary of the Research
The research report itself runs to 197 pages. These paragraphs are quoted directly from the Conclusion of the report.
The study product Arterosil®, composed of extracts from green algae, Monostroma nitidum, is effective in improving arterial health and function, lowering blood pressure and improving the lipid profile. This study provides additional knowledge on the effects of rhamnan sulfates on endothelial function on healthy subjects. Arterosil© is safe and tolerable for consumption and no serious adverse events occurred in the study.
In the present study, the effects of the Arterosil® containing the extracts of Monostroma nitidum on protecting the health of the glycocalyx when subjected to a standardized high-fat and high glycemic meal challenge was determined. Healthy subjects 25 to 65 years of age with a BMI of 18 to 35 were included in the study. A total of 22 subjects were randomized to receive the study product.
The primary objective of the study was to assess the effects of Arterosil on supporting arterial functions and maintaining healthy blood pressure levels. The findings of the study show that the study product was effective in significantly decreasing augmentation index, a measure of arterial stiffness (Moerland, 2012). Moreover, the study product was proven effective in significantly improving systolic and diastolic blood pressure. Other findings of the study included significantly decreased LDL cholesterol after intake of the study product. These results demonstrate the efficacy in improving arterial health and function as well as the antihypertensive and antihypercholesterolemic properties of the Arterosil© study product.
The most widely recognized bioactivity of sulfated polysaccharides is the anticoagulant activity exhibited by fucoidans and fucans of brown algae. Sulfated galactans and polysaccharides, other than fucans, can also be obtained from green algae. Nakamura (2011) isolated rhamnan sulfate from Monostroma nitidum and the yield was 2.5% W/W. Moreover, Hayakawa (2000), demonstrated that sulfated polysaccharides isolated from green algae decreased the inhibition of thrombin more effectively than the standard heparin. In another study, two sulfated rhamnose-containing polysaccharides from Monostoma nitidum were isolated and their anticoagulant activities were studied. The findings of the study showed that both sulfate polysaccharides possess high anticoagulant activities and were potent thrombin inhibitors mediated by heparin cofactor II (Mao, 2008).
A human clinical study evaluating the effects of rhamnan sulfate from green alga, Monostroma latissium and Monostroma nitidum, for 6 weeks, demonstrated significant reductions in total cholesterol and LDL cholesterol levels (Masakatsu, 2006). In another study, funoran, a sulfated polysaccharide from red algae, was demonstrated to cause significant reduction in systolic blood pressure, total and free cholesterol, triglyceride, LDL-cholesterol and atherogenic index in rats (Ren, 1994).
Few studies on the anti-hyperlipidemic and hypertensive effects of Monostroma nitidum extracts were completed on human subjects and the exact mechanism is not yet fully understood. However, in the funoran study, the authors demonstrated that the enhanced ability to excrete sodium in urine by the funoran diet is an important factor to lower blood pressure. Moreover, according to them, the antihyperlipidemic effect of furonan was due to the enhanced excretion of cholesterol in feces (Ren, 1994).
In conclusion, the results of this study showed that the extracts from green algae, Monostoma nitidum, significantly improved arterial health and function, reduced blood pressure, and lowered cholesterol levels. No serious adverse events occurred in the study. The study product was safe and tolerable for consumption.